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AJNR - American Journal of Neuroradiology

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Late Proton MR Spectroscopy in Children after Traumatic Brain Injury: Correlation with Cognitive Outcomes

Jill V. Hunter^a,c, Robert J. Thornton^a,c, Zhiyue J. Wang^a,c, Harvey S. Levin^b, Garland Roberson^b, William M. Brooks^e and Paul R. Swank^d

^a Department of O.I., Baylor College of Medicine
^b Department of Physical Medicine and Rehabilitation, Baylor College of Medicine
^c Texas Children’s Hospital
^d the Department of Pediatrics, University of Texas Health Science Center, Houston, TX
^e the Hoglund Imaging Center, University of Kansas Medical Center, Kansas City

View larger version (67K): [in a new window]   FIG 1. Position of the spectroscopic imaging VOI, as viewed in the axial and sagittal planes. On the axial image, the outlined sections inside the VOI depict voxels typically selected for the four regions of interest, and the pattern surrounding the VOI is the area covered by the eight multiple regional saturation technique (MREST) pulses for saturating lipid signals from the scalp.

View larger version (26K): [in a new window]   FIG 2. Average spectra obtained from the left frontal lobe of a patient versus that of a control demonstrates a decrease in NAA after TBI.