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AJNR - American Journal of Neuroradiology

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Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine

Marc Tardieu^a, Francis Brunelle^b, Charles Raybaud^c, William Ball^f, Béatrice Barret^d, Brigitte Pautard^e, Eric Lachassine^f, Marie-Jeanne Mayaux^d and Stéphane Blanche^e

^a Department of Pediatric Neurology, Hôpital Bicêtre AP-HP, Le Kremlin Bicêtre
^b Department of Pediatric Radiology, Hôpital Necker AP-HP, Paris
^c Department of Neuroradiology, Hôpital de la Timone, Marseille
^d Department of Epidemiology, Demographics, and Social Sciences, Amiens
^e Department of Pediatrics, Hôpital Nord, Amiens
^f Hôpital Jean Verdier AP-HP, Bondy
^g Department of Pediatric Immunology and Hematology, France
^h Department of Radiology, Cincinnati Children’s Hospital Medical Center, OH

View larger version (79K): [in a new window]   FIG 1. Image in a boy aged 1 year 5 month with cognitive delay, dystonia, and nystagmus. Results of muscular biopsy established mitochondrial dysfunction. Axial T2-weighted MR image shows diffuse hyperintensity in the periventricular white matter. Note bilateral areas of necrosis.

View larger version (79K): [in a new window]   FIG 2. Image in a boy aged 10 months with severe cognitive delay and repeated seizures. Results of muscular biopsy established mitochondrial dysfunction. Axial FLAIR MR image shows diffuse hyperintensity in the tegmentum pons, basilar pons, and cerebellar vermis.

View larger version (93K): [in a new window]   FIG 3. Image in an asymptomatic boy aged 2 years. Axial FLAIR MR image shows hyperintensity in the bilateral periventricular white matter in the posterior trigonal regions.

View larger version (93K): [in a new window]   FIG 4. Image in an asymptomatic boy aged 2 years. Axial T2-weighted MR image shows hyperintensity of the brainstem and around the dentate nuclei.