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Age-Related Changes in Normal-Appearing Brain Tissue and White Matter Hyperintensities: More of the Same or Something Else?

Aart Spilta, Tychon Geeraedtsa, Anton J. M. de Craenb, Rudi G. J. Westendorpb, Gerard J. Blauwb and Mark A. van Buchema

a Department of Radiology, Leiden University Medical Center, the Netherlands
b Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, the Netherlands



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  		FIG 1. T2-weighted images in two subjects. Segmentation was done on a section above the ventricles (B and E). In C and F, segmentation of NAWM is shown.

A–C, Subject with few WM hyperintensities.

D–F, Subject with more extensive WM hyperintensities.



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  		FIG 2. Mean MTR values in elderly study subjects, stratified by Scheltens score. Error bars = SEM.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X