Measurement of Tumor "Size" in Recurrent Malignant Glioma: 1D, 2D, or 3D?
Mary F. Dempseya,
Barrie R. Condona and
Donald M. Hadleyb
a Department of Clinical Physics, Institute of Neurological Sciences, Southern General Hospital, Glasgow
b Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, Glasgow

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FIG 1. Image showing software used (developed for Alkermes, Inc., by Evergreen Technologies, Inc., 00000, ME) by neuroradiologist to outline areas of enhancement manually on each transverse section to determine tumor volume.
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FIG 2. Tumor size measured using 1D and 2D techniques. A, 1D versus 2D technique plotted showing line of equality (r = 0.85; P < .05), B, Difference versus mean of tumor size measured by the two methods.
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FIG 3. Tumor size measured using 1D and 3D techniques. A, 1D versus 3D technique plotted showing line of equality (r = 0.44; P < .05). B, Difference versus mean of tumor size measured by the two methods.
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FIG 4. Tumor size measured by 2D and 3D techniques. A, 2D versus 3D technique plotted showing line of equality (r = 0.47; P < .05). B, Difference versus mean of tumor size measured by the two methods.
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