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AJNR - American Journal of Neuroradiology

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Tissue at Risk Is Overestimated in Perfusion-Weighted Imaging: MR Imaging in Acute Stroke Patients without Vessel Recanalization

Thomas Kucinski^a, Dirk Naumann^a, René Knab^b, Volker Schoder^c, Susanne Wegener^d, Jens Fiehler^a, Amitava Majumder^a, Joachim Röther^b and Hermann Zeumer^a

^a Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
^b Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
^c Institute for Medical Biometry and Epidemiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
^d University Hospital Berlin Charité, Berlin, Germany

View larger version (89K): [in a new window]   FIG 1. Illustration of lesion definitions on a representative ADC image at day 0. Lesion on day 0 in black = ADC lesion at day 0; dark gray = lesion growth until day 1 (LG1); pale gray = lesion growth until day 7 (LG7); white = surviving tissue (ST7). LG1 and LG7 were found by surrounding follow-up T2 lesions at day 1 and 7 and transfer onto day 0 PWI images. ST7 is tissue initially showing CBF decrease but without T2 changes at day 7.

View larger version (36K): [in a new window]   FIG 2. Relative contribution of the three most frequent occlusion types to the total lesion volumes at day 0 (L0) or lesion growth LG1 and LG7. 100% is the sum of the lesions volumes of the three occlusion types.