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AJNR - American Journal of Neuroradiology

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Detectability of Hypometabolic Regions in Mild Alzheimer Disease: Function of Time after the Injection of 2-[Fluorine 18]-Fluoro-2-Deoxy-D-Glucose

Setsu Sakamoto^a,b, Kazunari Ishii^a, Kayo Hosaka^a,c, Tetsuya Mori^a, Masahiro Sasaki^a,d and Etsuro Mori^a

^a Departments of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, Himeji
^b Division of Image-Based Medicine, Institute of Biomedical Research and Innovation, Kobe
^c Department of Radiology, Kobe University School of Medicine, Japan
^d PET Center, Himeji Central Hospital, Hyogo, Japan

View larger version (82K): [in a new window]   FIG 1. Comparison of patients with AD and healthy control subjects by using SPMs. Highlighted areas indicate regions with significantly decreased FDG uptake (P < .001). A, ES at 30 minutes after FDG injection. B, LS at 60 minutes after FDG injection.

View larger version (64K): [in a new window]   FIG 2. Areas of low regional cerebral FDG uptake shown on SPMs in healthy subjects at ES (30 minutes) versus LS (60 minutes).

View larger version (12K): [in a new window]   FIG 3. Z-score images of a 67-year-old woman AD (Mini-Mental State Examination score of 23, Alzheimer’s Disease Assessment Scale score of 20) at ES (top) and at LS (bottom). Distribution of areas of significantly decreased FDG uptake are larger and the height of the Z score is larger on the LS image than on the ES image, especially in the posterior cingulate gyrus and precuneus. Views: RT.LAT = right lateral, LT.LAT = left lateral, SUP = superior, INF = inferior, ANT = anterior, POST = posterior, RT.MED = right medial, LT.MED = left medial.