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AJNR - American Journal of Neuroradiology

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Optic Nerve Diffusion Measurement from Diffusion-Weighted Imaging in Optic Neuritis

Simon J. Hickman^a,b, Claudia A. M. Wheeler-Kingshott^a, Stephen J. Jones^c, Katherine A. Miszkiel^d, Gareth J. Barker^a,e, Gordon T. Plant^b and David H. Miller^a

^a NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
^b Department of Neuro-Ophthalmology, Moorfields Eye Hospital, London, United Kingdom
^c Department of Clinical Neurophysiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
^d Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
^e Institute of Psychiatry, Kings College London, London, United Kingdom

View larger version (64K): [in a new window]   FIG 1. Orbital images from a 36-year-old woman 1 year after right-sided optic neuritis. Diseased optic nerve indicated by arrowhead, and contralateral healthy optic nerve indicated by arrow. A, Nondiffusion weighted (b = 0) image. B, ADC map. C, FSE image demonstrating high signal intensity lesion in the right optic nerve. D, sTE fFLAIR image demonstrating right optic nerve atrophy.

View larger version (23K): [in a new window]   FIG 2. Scatter graph showing ADCs for diseased optic nerves 1 year after acute optic neuritis, healthy contralateral optic nerves, and control optic nerves.

View larger version (16K): [in a new window]   FIG 3. Association between logMAR visual acuity and diseased optic nerve ADC (rS = 0.73; P = .001).

View larger version (16K): [in a new window]   FIG 4. Association between 1-year VEP central field amplitude and diseased optic nerve ADC (rS = –0.57, P = .021).