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AJNR - American Journal of Neuroradiology

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Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases

Leandro T. Lucato^a, Maria Concepción G. Otaduy^a, Egberto R. Barbosa^b, Alexandre A. C. Machado^b, Alexander McKinney^c, Luiz A. Bacheschi^b, Milberto Scaff^b, Giovanni G. Cerri^a and Claudia C. Leite^a

^a Department of Radiology, the Clinics Hospital of the University of Sao Paulo, School of Medicine, Brazil
^b Department of Neurology, the Clinics Hospital of the University of Sao Paulo, School of Medicine, Brazil
^c Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis

View larger version (67K): [in a new window]   FIG 1. Axial T2-weighted fast spin-echo images (TR/TE = 3000/88.8, echo train length = 22) show the VOIs for MRS. A, In the BG. B, In the FWM. C, In the POC.

View larger version (14K): [in a new window]   FIG 2. Representative STEAM spectra (TR/TE = 2000/30) in the BG. A, Spectrum in a patient with WD shows reduction of the NAA peak relative to the Cr peak, with augmentation of the mI peak. B, Spectrum in a control subject obtained in the same location.

View larger version (10K): [in a new window]   FIG 3. Scatterplot shows NAA/Cr and mI/Cr ratios in the BG in patients with WD and in control subjects.