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AJNR - American Journal of Neuroradiology

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Metabolite Phantom Correction of the Nonuniform Volume-Selection Profiles in MR Spectroscopic Imaging: Application to Temporal Lobe Epilepsy

J. O. Jesper Lundbom^a, Kim E. Vuori^a, Eija K. Gaily^b, R. I. Marja-Liisa Granström^b, Göran C. Blomstedt^c, Anna-Maija Häkkinen^d, Sami M. Heikkinen^a and Nina M. I. Lundbom^a

^a Helsinki Medical Imaging Center, Helsinki University Central Hospital, Finland
^b Department of Pediatric Neurology, Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland
^c Department of Neurosurgery, Helsinki University Central Hospital, Finland
^d Department of Oncology, Helsinki University Central Hospital, Finland

View larger version (176K): [in a new window]   FIG 1. Axial/coronal T1-weighted image at the level of the hippocampi with the MRSI voxels 1, 2, and 3 chosen to represent the hippocampus. The 100- and 80-mm-wide VOIs are shown (white rectangles).

View larger version (20K): [in a new window]   FIG 2. Phantom profile for water signal intensity with the 180° Hamming-weighted sinc pulse of the PRESS CSI sequence (solid line with black boxes) obtained by selecting the right-left dimension of the 100-mm VOI (vertical lines). Profile shifted by 10 mm (dashed line with white boxes). This displacement approximately corresponds to the chemical-shift difference between water and NAA with the typical excitation bandwidth of 1500 Hz for the section-selective 180° pulse. Images shows the difference between the original profile and the shifted profile spanning the VOI (dotted line with gray circles). The water intensity on the y axis is expressed in institutional units (i.u.), and the x axis corresponds to the 10-mm voxels in the 160-mm FOV.