Relationship between Brain Tissue Oxygen Tension and CT Perfusion: Feasibility and Initial Results
J. Claude Hemphill, IIIa,
Wade S. Smitha,
D. Christian Sonneb,
Diane Morabitoc,e and
Geoffrey T. Manleyd,e
a Department of Neurology, University of California, San Francisco
b Department of Radiology, University of California, San Francisco
c Department of Surgery, University of California, San Francisco
d Department of Neurosurgery, University of California, San Francisco
e San Francisco Injury Center
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FIG 1. Patient who underwent hemicraniectomy after head trauma.
A, Nonenhanced CT scan shows the tip of the brain-tissue oxygen probe as a white linear attenuation in the right hemispheric white matter. Midline white attenuation is a ventriculostomy catheter. Yellow circle indicates the ROI for CTP analysis.
B, CTP color map of MTT. On the reference bar, blue indicates the slowest MTT. Arrow points to the tip of the oxygen probe. Overall, MTT is decreased on the side of hemicraniectomy, indicating more rapid transit. Surrounding blue rim represents scalp perfusion.
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FIG 2. Plots of PbrO2.
A, PbrO2 is inversely and significantly correlated with MTT (P = .017).
B and C, PbrO2 is not significantly related to CBV or CBF.
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