A Widespread Pattern of Cortical Activations in Patients at Presentation with Clinically Isolated Symptoms Is Associated with Evolution to Definite Multiple Sclerosis
Maria A. Roccaa,
Domenico M. Mezzapesaa,
Angelo Ghezzid,
Andrea Falinib,
Vittorio Martinellic,
Giuseppe Scottia,
Giancarlo Comic and
Massimo Filippia
a Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
b Department of Neuroradiology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
c Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
d Department of Neurology, Ospedale di Gallarate, Gallarate, Italy
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FIG 1. Color-coded SPMt maps superimposed on a high-spatial-resolution T1-weighted image showing relative cortical activations during a simple motor task with the dominant, functionally normal right hand in patients with clinically isolated syndromes suggestive of MS that did not evolve to definite MS compared with those who did (random effect analysis, between-group comparison, corrected P value < .05).
A, Ipsilateral paracentral lobule.
B, Contralateral primary somatomotor cortex and supplementary motor area.
C, Ipsilateral cerebellar hemisphere.
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FIG 2. Color-coded SPMt maps superimposed on a high-spatial-resolution T1-weighted image showing relative cortical activations during a simple motor task with the dominant, functionally normal right hand in patients with clinically isolated syndromes that evolved to MS as compared with those who did not (random effect analysis, between-group comparison, corrected P value < .05).
A, Ipsilateral infraparietal sulcus.
B, Bilateral superior frontal sulcus.
C, Ipsilateral superior frontal gyrus and middle frontal gyrus and contralateral infraparietal sulcus.
D, Ipsilateral superior temporal gyrus.
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