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AJNR - American Journal of Neuroradiology

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Hippocampal Alterations in Children with Temporal Lobe Epilepsy with or without a History of Febrile Convulsions: Evaluations with MR Volumetry and Proton MR Spectroscopy

Wen-Chau Wu^a,c, Chao-Ching Huang^d, Hsiao-Wen Chung^a,c, Michelle Liou^b, Chun-Jen Hsueh^a, Chang-Shin Lee^a, Ming-Long Wu^c and Cheng-Yu Chen^a

^a Department of Radiology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan, Republic of China
^b Institute of Statistics Science, Taipei, Taiwan, Republic of China
^c Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, Republic of China
^d Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan, Republic of China

View larger version (43K): [in a new window]   FIG 1. Segmentation procedure. After manually tracing the in-plane boundaries, histogram-based segmentation was used to categorize the region of interest into CSF (black), gray matter (gray), and white matter (white). Only pixels of gray matter are counted to exclude the region of gliosis and atrophy.

View larger version (17K): [in a new window]   FIG 2. For each subject, two sides of HV are divided into large and small sides. In the control group, the asymmetry index (AIv) is 2.2% on average. The plot shows different relationships among three groups in large and small sides. The interaction between groups and sides is statistically significant (P < .01).

View larger version (15K): [in a new window]   FIG 3. For each subject, two sides of NAA/(Cho + Cr) ratios are divided into large and small sides. The asymmetry index (AIs) scatters in a wide range. In the control group, the AIs is 0.77 on the average. The plot shows that the relationships among three groups in large and small sides are quite parallel. There is a trend of lowering NAA/(Cho + Cr) ratios in TLE + FC, but no statistical interaction between groups and sides was found (P = .272).