Well-Circumscribed, Minimally Enhancing Glioblastoma Multiforme of the Trigone: A Case Report and Review of the Literature
Paul Parka,
Vaishali R. Choksib,d,
Vishal C. Galaa,
Asha R. Kazab,d,
Hedwig S. Murphyc and
Suresh Ramnatha
a Department of Neurosurgery, University of Michigan Health System, Ann Arbor, MI
b Department of Radiology, University of Michigan Health System, Ann Arbor, MI
c Department of Pathology, University of Michigan Health System, Ann Arbor, MI
d V. A. Ann Arbor Healthcare System, Ann Arbor, MI
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FIG 1. Precontrast (A) and postcontrast (B) CT images showing a large, poorly enhancing mass that appears to be within the right lateral ventricle.
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FIG 2. Precontrast coronal (A), postcontrast coronal (B), postcontrast axial (C), and T2-weighted axial (D) MR images redemonstrating a minimally enhancing mass within the trigone. The mass is homogenous and well-defined and appears to cause local expansion of the ventricle.
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FIG 3. Glioblastoma multiforme. Gemistocytes were the most common cell type within the neoplasm (A; hematoxylin and eosin, original magnification x400). Immunostains for GFAP (B), neurofilament (C), and S-100 protein (D), are all at original magnification x400. Areas of vascular endothelial cell proliferation and necrosis (E and F, respectively; original magnification x100) characterize this lesion as a grade IV GBM.
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