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AJNR - American Journal of Neuroradiology

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Dilatation of the Virchow-Robin Space Is a Sensitive Indicator of Cerebral Microvascular Disease: Study in Elderly Patients with Dementia

Tufail F. Patankar^a, Dipayan Mitra^a, Anoop Varma^b, Julie Snowden^b, David Neary^b and Alan Jackson^a

^a Institutions Imaging Science and Biomedical Engineering, School of Medicine, University of Manchester, UK
^b Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK

View larger version (77K): [in a new window]   FIG 1. Matching axial MR images show severe (grade 5) dilatation of the VRS (matrix = 256 x 256, FOV = 230 x 230 mm): A, T2-weighted variable echo (TR/TE1/TE2 = 5500/20/90); B, T1-weighted high-spatial-resolution T1-weighted 3D gradient echo (TR/TE = 24/18, section thickness = 0.89 mm, flip angle = 30°); and C, inversion recovery (TR/TE/TE = 6850/18/300). Calculated CNRs for VRS versus WM are 64.1 for inversion recovery, 24.8 for fast field-echo, 19.1 for the variable-echo second-echo imaging.

View larger version (79K): [in a new window]   FIG 2. Axial inversion recovery MR images (TR/TE/TI = 6850/18/300, matrix = 256 x 256, FOV = 230 x 230 mm) show grade 3 VRS dilatation (arrows).

View larger version (149K): [in a new window]   FIG 3. Axial inversion recovery MR images (TR/TE/TI = 6850/18/300, matrix = 256 x 256, FOV = 230 x 230 mm) show extensive VRS dilatation (arrows) throughout the BG (grade 5).

View larger version (80K): [in a new window]   FIG 4. Axial Inversion recovery MR images (TR/TE/TI = 6850/18/300, matrix = 256 x 256, FOV = 230 x 230 mm) show the VRS (arrows) as linear structure passing through several sections (A–C) in the imaging volume.