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AJNR - American Journal of Neuroradiology

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Cerebral Perfusion Alterations during the Acute Phase of Experimental Generalized Status Epilepticus: Prediction of Survival By Using Perfusion-Weighted MR Imaging and Histopathology

T. Engelhorn^a, A. Doerfler^a, J. Weise^c, M. Baehr^c, M. Forsting^a and A. Hufnagel^b

^a Department of Neuroradiology, University of Essen, Essen, Germany
^b Department of Neurology, University of Essen, Essen, Germany
^c Department of Neurology, University of Goettingen, Goettingen, Germany

View larger version (96K): [in a new window]   FIG 1. Regions of interest used for quantitative analysis. A, Representative MR image on which regions of interest are outlined. B, Schematic drawing of a rat brain at similar level with identical regions of interest superimposed. regions of interest were defined as: retrosplenial parietal and temporal cortex (RCp and RCt), piriform cortex (PC), hippocampus (Hippo), thalamus (Thal), and amygdala (Amy).

View larger version (14K): [in a new window]   FIG 2. Averaged BPRs in the retrosplenial parietal cortex of pilocarpine-treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions. A double asterisk denotes significant increase compared with baseline conditions.

View larger version (14K): [in a new window]   FIG 3. Averaged BPRs in the retrosplenial temporal cortex of pilocarpine -treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions. A double asterisk denotes significant increase compared with baseline conditions.

View larger version (14K): [in a new window]   FIG 4. Averaged BPRs in the piriform cortex of pilocarpine-treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions. A double asterisk denotes significant increase compared with baseline conditions.

View larger version (13K): [in a new window]   FIG 5. Averaged BPRs in the thalamus of pilocarpine-treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions.

View larger version (14K): [in a new window]   FIG 6. Averaged BPRs in the amygdala of pilocarpine-treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions. A double asterisk denotes significant increase compared with baseline conditions.

View larger version (14K): [in a new window]   FIG 7. Averaged BPRs in the hippocampus of pilocarpine-treated animals at baseline conditions and at 3, 15, 30, 60, and 120 minutes after pilocarpin-induced SE, respectively. An asterisk denotes significant decease compared with baseline conditions. A double asterisk denotes significant increase compared with baseline conditions.