1H MR Spectroscopic Characteristics of Kernicterus: A Possible Metabolic Signature
Wendy K. Oakdena,c,
Aideen M. Moored,
Susan Blaserc,e and
Michael D. Noseworthya,b,e
a Imaging Research Centre, Brain Body Institute, St Joseph’s Healthcare, Hamilton, Ontario, Canada
b Departments of Radiology and Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, Ontario, Canada
c Department of Diagnostic Imaging, University of Toronto, Ontario, Canada
d Department of Neonatology, the Hospital for Sick Children, University of Toronto, Ontario, Canada
e Department of Medical Imaging, University of Toronto, Ontario, Canada
View larger version (112K):
[in a new window]
|
FIG 1. Axial T1-weighted (TR/TE = 516/9) MR image shows abnormal hyperintensity in the globus pallidus (arrows) in an infant with kernicterus.
| |
View larger version (27K):
[in a new window]
|
FIG 2. Patient 4. LCModel analysis from a spectrum obtained at TE = 144 msec. Obtained (light) spectrum is overlaid on the fitted (bold) plot. Residual plot (fitted minus observed) is normally distributed about a mean of 0, indicating an excellent global-model fit.
| |
View larger version (19K):
[in a new window]
|
FIG 3. Metabolite ratios relative to Cr in infants with suspected kernicterus based on T1- and T2-weighted imaging findings (kernicterus) compared with normal values (normals). Tau/Cr, Glx/Cr, and mI/Cr were significantly elevated (*; P < .001), whereas Cho/Cr was significantly decreased (**; P < .001).
| |
