Diffuse Cortical Necrosis in a Neonate with Incontinentia Pigmenti and an Encephalitis-Like Presentation
Nicole I. Wolfa,
Nikola Krämer,
Inga Hartingc,
Angelika Seitzc,
Friedrich Ebingera,
Johannes Pöschlb and
Dietz Ratinga
a Department of Pediatric Neurology, University Children’s Hospital Heidelberg, Germany
b Department of Neonatology, University Children’s Hospital Heidelberg, Germany
c Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany
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FIG 1. MR imaging on the 3rd day of life (A–D) and at the age of 5 months (E and F).
A and B, T1-weighted images. The sagittal view (B) illustrates the extensive cortical damage including cerebellar cortex.
C and D, Axial T2-weighted images, demonstrating high signal intensity in the subcortical white matter mainly of the left hemisphere and also signal intensity changes of almost the entire left cortex. On T1-weighted images, these white matter areas appear hypointense (A). E and F, At follow-up, fluid-attenuated inversion recovery images show residual cystic lesions, more on the left than on the right, involving mainly subcortical white matter and also cortical areas. There is no normal signal intensity of myelination. Basal ganglia appear atrophic on the left (F).
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