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Angiographic and Histologic Analysis of Experimental Aneurysms Embolized with Platinum Coils, Matrix, and HydroCoil

Yong Hong Dinga, Daying Daia, Debra A. Lewisa, Harry J. Clofta and David F. Kallmesa

a From the Department of Radiology, Mayo Clinic, Rochester, MN



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  		FIG 1. Number 3 aneurysm in Matrix group, 2-week implant.

A, Anteroposterior DSA of the brachiocephalic artery shows a moderately wide-necked aneurysm.

B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows near-complete occlusion of the aneurysm.

C, Anteroposterior DSA obtained 2 weeks after embolization shows marked coil compaction.

D, Hematoxylin and eosin stain; original magnification, x1.5. Coronal section obtained through the aneurysm cavity. Microcompaction and inflammation along neck are shown.

E, Hematoxylin and eosin stain; original magnification, x25. Magnification of the area shown in panel D; substantial inflammation is shown along neck.



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  		FIG 2. Number 9 aneurysm in Matrix group, 10-week implant.

A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.

B, Anteroposterior DSA obtained immediately after embolization with Matrix coils shows the aneurysm is nearly completely occluded.

C, Anteroposterior DSA obtained 2 weeks after embolization shows slight coil compaction.

D, Hematoxylin and eosin stain; original magnification, x1.3. Coronal section obtained through the aneurysm cavity. Marked microcompaction and unorganized thrombus are shown. There is no tissue across the aneurysm neck.

E, Hematoxylin and eosin stain; original magnification, x25. Magnification of the area shown in panel D. Dense cellular infiltration near coils in the dome is seen.



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  		FIG 3. Number 15 aneurysm in HydroCoil group, 6-week implant.

A, Anteroposterior DSA of the brachiocephalic artery shows a wide-necked aneurysm.

B, Anteroposterior DSA obtained immediately after embolization with HydroCoils shows the aneurysm is nearly completely occluded.

C, Anteroposterior DSA obtained 2 weeks after embolization shows the aneurysm remaining stable.

D, Hematoxylin and eosin stain; original magnification, x1.1. Coronal section obtained through the aneurysm cavity. No substantial inflammatory response is present. Microcompaction is absent. A small part of persistent unorganized thrombus is shown in the aneurysm dome.

E, Hematoxylin and eosin stain; original magnification, x10. Magnification of the area shown in panel D. Cellular fibrous tissue is shown across the neck.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X