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AJNR - American Journal of Neuroradiology

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Hypoattenuation on CT Angiographic Source Images Predicts Risk of Intracerebral Hemorrhage and Outcome after Intra-Arterial Reperfusion Therapy

Lee H. Schwamm^a, Eric S. Rosenthal^a, Clifford J. Swap^a, Jonathan Rosand^a, Guy Rordorf^a, Ferdinando S. Buonanno^a, Mark G. Vangel^b, Walter J. Koroshetz^a and Michael H. Lev^b

^a Department of Neurology, Massachusetts General Hospital, Boston, MA
^b Department of Radiology, Massachusetts General Hospital, Boston, MA

View larger version (44K): [in a new window]   FIG 1. Schematic (A) and contrast-enhanced (B) CTA source images display region-of-interest segmentation. Single-section total lesion volume is the entire region of hypoattenuation on the section containing the core (TL, green). Single-section lesion core is the region of maximal hypoattenuation in the right insula (C, dark blue), compared with normal mirror-image tissue in contralateral left insula (NL, light blue).

View larger version (18K): [in a new window]   FIG 2. Relationship between HU of the lesion core and the likelihood of hemorrhage after IA reperfusion therapy. A, ROC curve from which an optimal HU threshold was selected. B, Scatterplot of patients with or without HT after IA reperfusion therapy.