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AJNR - American Journal of Neuroradiology

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Regional Lobar Atrophy Predicts Memory Impairment in Multiple Sclerosis

Ralph H. B. Benedict^a,b, Robert Zivadinov^a,c, Dominic A. Carone^a,b, Bianca Weinstock-Guttman^a,b, Jeff Gaines^a, Cosimo Maggiore^c, Jitendra Sharma^a,b, Maria-Antonietta Tomassi^c and Rohit Bakshi^a,b,d

^a Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY
^b Jacobs Neurological Institute, Buffalo, NY
^c Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
^d Center for Neurological Imaging, Harvard Medical School, Boston, MA

View larger version (54K): [in a new window]   FIG 1. Regional brain atrophy measurement of the temporal lobes in a patient with secondary progressive multiple sclerosis. The top figure shows coronal 3D spoiled gradient-recalled acquisition in the steady state T1-weighted source image used for the segmentation of the temporal lobes. Panels A and C show the brain parenchyma–only and cerebrospinal fluid–only images of the right temporal lobe. Panels B and D show the same type of segmentation outputs in the left temporal lobe.