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AJNR - American Journal of Neuroradiology

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Prediction of Treatment Response in Head and Neck Cancer by Magnetic Resonance Spectroscopy

Tedros Bezabeh^a, Olva Odlum^a,b, Richard Nason^a,c, Paul Kerr^a,c, Donna Sutherland^a,c, Rakesh Patel^a and Ian C.P. Smith^a

^a From the Institute for Biodiagnostics, National Research Council, University of Manitoba, Canada
^b Faculty of Dentistry, University of Manitoba, Canada
^c CancerCare Manitoba, Winnipeg, Manitoba, Canada

View larger version (18K): [in a new window]   FIG 1. 360 MHz 1H MR spectra of head and neck tumors (A) control (B) failed case. Both specimens came from oral tongue tumors. Chos, choline-containing compounds; Cr, creatines; Gln, glutamine; Glu, glutamic acid; HOD, deuteriated water; Lac, lactic acid; Leu, leucine; Lip, lipid; Tau, taurine; Val, valine. Assignments do not imply that these are the only substances contributing to a particular peak.

View larger version (11K): [in a new window]   FIG 2. Bar graphs of the 3.2/3.0 spectral intensity ratio (mean ± SEM). Dark shade, control; light shade, failed cases; A, tumors from all sites included; B, tumors of the tongue only.

View larger version (11K): [in a new window]   FIG 3. Bar graphs of the 1.3/0.9 spectral intensity ratio (mean ± SEM). Dark shade, control; light shade, failed cases; A, tumors from all sites included; B, tumors of the larynx only.