Hypoxic-Ischemic Brain Injury in the Neonatal Rat Model: Relationship between Lesion Size at Early MR Imaging and Irreversible Infarction
Y. Wanga,
P.-T. Cheungb,
G.X. Shend,
E.X. Wuc,
G. Caoe,
I. Bartb,
W.H.S. Wongb and
P.-L. Khonga
a Department of Diagnostic Radiology University of Hong Kong, Hong Kong, China; and GE Medical Systems, Asia, China
b Department of Pediatric and Adolescent Medicine, University of Hong Kong, Hong Kong, China; and GE Medical Systems, Asia, China
c Jockey Club MRI Centre, University of Hong Kong, Hong Kong, China; and GE Medical Systems, Asia, China
d MRI Laboratory, University of Hong Kong, Hong Kong, China; and GE Medical Systems, Asia, China
e Department of Electronic and Electrical Engineering, University of Hong Kong, Hong Kong, China; and GE Medical Systems, Asia, China
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Fig 1. Coronal ADC map of the rat brain taken 1–2 hours post-HI shows the measurement of the area of reduced ADC by using a relative ADC threshold of 80% of the mean contralateral hemisphere ADC intensity.
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Fig 2. Coronal T2WI (A) and DWI (B) sections of the rat brain at the level of the thalamus taken 1–2 hours post-HI show hyperintense areas in the right cerebral hemisphere, which are larger and more conspicuous on DWI than T2WI.
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Fig 3. Scatterplot of ln(%LV on 80% ADC threshold) at early imaging versus %LV on histopathology.
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