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AJNR - American Journal of Neuroradiology

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Direct Visualization of the Human Subthalamic Nucleus with 3T MR Imaging

K.V. Slavin, K.R. Thulborn, C. Wess and H. Nersesyan

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Ill
Magnetic Resonance Research Center, University of Illinois at Chicago, Chicago, Ill

View larger version (43K): [in a new window]   Fig 1. T2-weighted fast spin-echo images in the sagittal (A: TR, 6200 milliseconds; TE, 108 milliseconds), coronal (B: TR, 5650 milliseconds; TE, 95 milliseconds), and axial (C: TR, 6117 milliseconds; TE, 95 milliseconds) planes through the subthalamic nucleus. The stereotactic target is marked with a black arrow.

View larger version (57K): [in a new window]   Fig 2. Magnified area of interest from Fig 1 in the sagittal (A), coronal (B), and axial (C) planes. R, red nucleus; SN, substantia nigra; ZI, zona incerta; CI, capsula interna; T, thalamus; LV, lateral ventricle; STN, subthalamic nucleus.

View larger version (62K): [in a new window]   Fig 3. Sample intraoperative microelectrode recording from a single neuron at the center of the STN calculated with preoperative 3T MR imaging. A, Real-time electrophysiologic recording. B, Single-cell spike registration screen.

View larger version (67K): [in a new window]   Fig 4. MR imaging in early follow-up period after the placement of deep-brain stimulation electrode in the STN documented at 1.5T. A, T2-weighted fast spin-echo image. B, Gradient recalled echo image. C, Fluid-attenuated inversion recovery image. The susceptibility artifacts from the electrodes are obscuring the STN contours.