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AJNR - American Journal of Neuroradiology

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2006: A Stroke Odyssey

Thomas A. Tomsick, MD, FACR^a

^a University of Cincinnati
Cincinnati, Ohio

View larger version (46K): [in a new window]   Fig 1. Modified Rankin scale 0–2 outcomes in pre-IMS, IMS I, and IMS II compared with historical control of NINDS study rtPA and placebo control groups. Time to IV treatment was significantly earlier in the NINDS rtPA trial (108 minutes) compared with that in the 3 IV/IA treatment groups (126, 139, 140 minutes).

View larger version (42K): [in a new window]   Fig 2. Percentage modified Rankin scale 0–2 compared with onset to IA rtPA bolus (following reduced-dose IV therapy). A trend toward better outcomes with earlier therapy is demonstrated. No difference of post-IV IA therapy begun at 4–5 hours, compared with IV therapy (NINDS rtPA), is also shown. In IMS I and II, IA therapy began within 5 hours.

View larger version (30K): [in a new window]   Fig 3. Percentage modified Rankin scale 0–2 versus baseline NIHSS score. Improved outcomes at higher NIHSS scores in pre-IMS and IMS I are achieved.