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AJNR - American Journal of Neuroradiology

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Patient-Specific Computational Fluid Dynamics Modeling of Anterior Communicating Artery Aneurysms: A Study of the Sensitivity of Intra-Aneurysmal Flow Patterns to Flow Conditions in the Carotid Arteries

M.A. Castro^a, C.M. Putman^b,c and J.R. Cebral^a

^a College of Sciences, Department of Computational and Data Sciences, George Mason University, Fairfax, Va
^b Department of Interventional Neuroradiology, Inova Fairfax Hospital, Fairfax Radiological Consultants, Fairfax, Va
^c Department of Neurosurgery, George Washington University School of Medicine, Washington, DC

View larger version (34K): [in a new window]   Fig 1. Construction of 2 vascular models of AComA aneurysms from bilateral 3D rotational angiograms. The top row corresponds to patient 1, whereas the bottom row corresponds to patient 2. From left to right, the columns show volume renderings of the 3D rotational angiograms obtained by contrast injection in the right and left ICAs, the coregistered 3D rotational angiograms, and the reconstructed vascular models.

View larger version (18K): [in a new window]   Fig 2. Flow waveforms used in the numeric models of aneurysm hemodynamics.

View larger version (43K): [in a new window]   Fig 3. Visualization of the inflow and intra-aneurysmal flow patterns: Instantaneous streamlines at peak systole of the base case (1) are plotted for patient 1 (A) and patient 2 (B). The streamlines originating in the left and right A1 segments are rendered in red and light blue, respectively. The dominance of the left inflow in patient 2 and the more symmetric inflow pattern of patient 1 can be clearly seen.

View larger version (42K): [in a new window]   Fig 4. Selected regions for comparison of WSSs obtained under different flow conditions. The left and right panels correspond to the aneurysms of patients 1 and 2, respectively.

View larger version (20K): [in a new window]   Fig 5. Average WSS magnitude over each region of patient 1 for the flow conditions listed in the Table. WSS magnitudes are in dynes per square centimeter, and time is in percentage of the cardiac cycle.

View larger version (21K): [in a new window]   Fig 6. Average WSS magnitude over each region of patient 2 for the flow conditions listed in the Table. WSS magnitudes are in dynes per square centimeter, and time is in percentage of the cardiac cycle.

View larger version (75K): [in a new window]   Fig 7. Visualizations of the instantaneous WSS distribution over the aneurysm of patient 1. Each column corresponds to each of the 4 selected instants of time defined in Fig 5. Each row corresponds to each of the 9 flow conditions listed in the Table. The regions defined in Fig 4 (left) are also shown for reference. WSS magnitudes range from 0 (blue) to 200 dyne/cm2 (magenta).

View larger version (64K): [in a new window]   Fig 8. Visualizations of the instantaneous WSS distribution over the aneurysm of patient 2. Each column corresponds to each of the 4 selected instants of time defined in Fig 6. Each row corresponds to each of the 9 flow conditions listed in the Table. The regions defined in Fig 4 (right) are also shown for reference. WSS magnitudes range from 0 (blue) to 200 dyne/cm2 (magenta).