Hippocampal Infolding Angle Changes during Brain Development Assessed by Prenatal MR Imaging
A. Righinia,
S. Zirpolia,
C. Parazzinia,
E. Bianchinia,
P. Scifob,
C. Salac and
F. Triulzia
a Radiology and Neuroradiology Department, Children’s Hospital V. Buzzi, ICP, Milan, Italy
b Nuclear Medicine Department, IRCCS San Raffaele, Milan, Italy
c Radiology Institute, University of Milan, Milan, Italy
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Fig 1. The method used to assess the hippocampal infolding angle (HIA) is shown on the coronal T2-weighted single-shot, fast spin-echo section encompassing the pons.
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Fig 2. Graph illustrating the significantly positive correlation between the HIA (average of values relative of both hemispheres) and the gestational age (GA).
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Fig 3. Coronal T2-weighted single-shot, fast spin-echo sections depicting the change of HIA value in 6 representative cases of different GA.
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Fig 4. Graph illustrating the average HIA value in the 5 GA groups into which the 62-fetus population was divided. The number (n) of fetuses for each group is reported. Bars indicate the 2 SD range.
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Fig 5. T2-weighted single-shot, fast spin-echo MR images from the fetal case reported in the "Discussion" section.
A and B, Two coronal sections from studies in gestational weeks 23 and 32, respectively, depicting at right temporal-occipital level the abnormal invagination of a cortical sulcus (black arrow). An additional abnormal smaller sulcus is visible (black arrowhead). The normal migrating cells band is focally thinned (white arrowhead). Note the integrity of ventricular wall, excluding the presence of a schizencephalic cleft.
C and D, Two axial sections from studies in gestational weeks 21 and 32, respectively, showing the early abnormal cortical sulcus (black arrow), followed later on by the development of multiple abnormal sulci (white arrows).
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Fig 6. Same case as Fig 5.
A and B, Two coronal T2-weighted single-shot, fast spin-echo sections from studies in gestational weeks 23 and 32, respectively, showing the abnormal value of the right HIA in comparison with the normal contralateral one.
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