Hippocampal Sulcus Width and Cavities: Comparison Between Patients with Alzheimer Disease and Nondemented Elderly Subjects
A.J. Bastos-Leitea,b,
J.H. van Waesberghea,
A.L. Oenc,
W.M. van der Flierd,
P. Scheltensd and
F. Barkhofd
a Department of Radiology and Image Analysis Center, VU University Medical Center, Amsterdam, the Netherlands
b Department of Neuroradiology, Hospital Geral de Santo António, Oporto, Portugal
c Department of Radiology, Laurentius Hospital, Roermond, the Netherlands
d Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands
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Fig 1. Magnified coronal high-resolution T1-weighted images of the hippocampal region.
A and B, Coronal T1-weighted image of a 68-year-old nondemented control showing discrete enlargement of the choroidal fissures (cf), suggesting medial temporal lobe atrophy (MTA) grade 1, and hippocampal cavities bilaterally (vertical arrows). Note that both hippocampal sulci are not enlarged (horizontal arrows).
C and D, Coronal T1-weighted image of a 54-year-old patient with Alzheimer disease showing enlargement of the hippocampal sulcus, measured between the fimbria and the subiculum (vertical measurement overlays), and enlargement of the choroidal fissures (cf) (MTA grade 1).
E and F, Coronal T1-weighted image of a 76-year-old patient with Alzheimer disease showing enlargement of the hippocampal sulcus (vertical measurement overlays), moderate-to-severe MTA (grade 3) and hippocampal cavities bilaterally (vertical arrows).
G and H, Coronal T1-weighted image of a 93-year-old patient with Alzheimer disease showing severe MTA (grade 4) and a small hippocampal cavity on the right side (vertical arrow). Note that the fimbria appears laterally displaced; this displacement contributes to an increase of the fimbriosubicular distance (oblique measurement overlays).
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Fig 2. Scatterplots displaying the averaged left/right hippocampal sulcus width (fimbriosubicular distance) plotted against the medial temporal atrophy score. Triangles represent patients with Alzheimer disease, and circles correspond to control subjects.
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