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AJNR - American Journal of Neuroradiology

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In Vivo Detection of Cortical Plaques by MR Imaging in Patients with Multiple Sclerosis

F. Bagnato^a,*, J.A. Butman^b,*, S. Gupta^a,c, M. Calabrese^a, L. Pezawas^d, J.M. Ohayon^a, F. Tovar-Moll^a, M. Riva^a, M.M. Cao^a, S.L. Talagala^e and H.F. McFarland^a

^a Neuroimmunology Branch, NINDS, Warren G. Magnuson Clinical Center, NIH, Bethesda, Md
^b Diagnostic Radiology Department, Warren G. Magnuson Clinical Center, NIH, Bethesda, Md
^c New York Medical College, Valhalla, NY
^d Genes, Cognition and Psychosis Program, NIH, Bethesda, Md
^e NIH-MRI Research Facility, NINDS, NIH, Bethesda, Md

View larger version (107K): [in a new window]   Fig 1. Average of 12 coregistered axial SPGR (A) and FLAIR (B) MR images demonstrate cortical MS lesions in patient 3. Several Type B cortical lesions traverse the gray-white boundary (white arrowheads, A, B). A single Type A lesion (white arrows A, B) is confined to the gray matter of the motor strip. Serial magnified images of the precentral gyrus (C-J) conform that this lesion (white arrows D-H) does not extend into the juxtacortical white matter.

View larger version (87K): [in a new window]   Fig 2. Average of 12 coregistered SPGR (A) and FLAIR (B) demonstrate a Type B cortical lesion in the right insula (arrowheads). Higher magnification of the averaged SPGR dataset in the axial (C), coronal (D), and sagittal (E) planes shows the relationship of the lesion to the cortical ribbon. (Patient 2).

View larger version (68K): [in a new window]   Fig 3. Coregistration and averaging 6 (B) and 12 (C) T1 SPGR MRI volumes improves conspicuity of cortical lesions (e.g. Type B lesion arrows, A-C) relative to a single SPGR (A). Although the Type B lesion is visible on the single SPGR (A), coregistering and averaging 6 (B) and 12 (C) SPGRs improves lesion conspicuity, and allows clear characterization of lesion location with respect to the gray-white boundary. (Patient 6).