MR Imaging of Human Herpesvirus-6 Encephalopathy after Hematopoietic Stem Cell Transplantation in Adults
T. Noguchia,
F. Miharaa,
T. Yoshiuraa,
O. Togaoa,
K. Atsumib,
T. Matsuurab,
T. Kuroiwac and
H. Hondaa
a Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
b Department of Radiology, Hamanomachi Hospital, Fukuoka, Japan
c Department of Radiology, National Kyushu Cancer Center, Fukuoka, Japan
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Fig 1. Axial MR images of an HHV-6 encephalopathy patient (patient 2) obtained on the second day after the onset of neurologic symptoms.
A, T1WI (TR/TE = 466/11 ms).
B, T2WI (2650/93 ms).
C, FLAIR (TR/TE/TI = 9000/97/2300 ms).
D, DWI (TR/TE = 3100/119 ms, b = 1000).
E, ADC map.
F, postcontrast T1WI (TR/TE = 558/17 ms).
An abnormal low signal intensity on T1WI (A) and high signal intensity on T2WI (B) and FLAIR (C) are shown in the bilateral amygdalae and hippocampi. High signal intensity on DWI (D) with ADC reduction (E) is also shown. However, no abnormal enhancement is seen on postcontrast T1WI (F).
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Fig 2. Serial axial MR images of a 49-year-old woman (patient 1) including FLAIR (TR/TE/TI = 9000/110/2200 ms [A, B, D] or 9000/97/2300 ms [C]), DWI (TR/TE = 4000/137 ms [E, F, H] or 3100/119 ms [G]), and ADC maps on days 1, 13, 26, and 98 after the onset of neurologic symptoms (I-L). On FLAIR, high signal intensity in the bilateral amygdalae and hippocampi appears on day 1, peaks on day 13, and becomes less pronounced on day 26, disappearing on day 98 but leaving marked atrophy. High signal intensity on DWI is observed until day 26, whereas ADC value reduction is seen only on days 1 and 13.
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