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AJNR - American Journal of Neuroradiology

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Effects of Dexamethasone on Cerebral Perfusion and Water Diffusion in Patients with High-Grade Glioma

M.E. Bastin^a, T.K. Carpenter^b, P.A. Armitage^b, S. Sinha^b, J.M. Wardlaw^b and I.R. Whittle^b

^a From the Department of Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
^b Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom

View larger version (49K): [in a new window]   Fig 1. Images obtained from patient 4. A, Presteroid treatment contrast-enhanced T1-weighted volume image with region of interest indicating enhancing tumor. Pre- (B) and 72 hours (C) poststeroid treatment T2-weighted EP images with shaded and unshaded region of interest indicating enhancing tumor and nonenhancing peritumoral edematous brain.

View larger version (109K): [in a new window]   Fig 2. Images obtained from patient 4. [<D>] (A and E), CBF (B and F), CBV (C and G), and MTT (D and H) maps obtained pre- (first row) and 72 hours poststeroid treatment. Note the reduction in [<D>] (red arrow) and the subtle increase in CBF for cortical/subcortical tissue within the edematous brain region (pink arrow). The maps are scaled to a maximum of 2500 x 10–6 mm2/s for [<D>], 75 mL/100 g/min for CBF, 7 mL/100 g for CBV, and 5 seconds for MTT.