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AJNR - American Journal of Neuroradiology

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Distribution Characteristics, Reproducibility, and Precision of Region of Interest–Based Hippocampal Diffusion Tensor Imaging Measures

M.J. Müller^a, M. Mazanek^b, C. Weibrich^b, P.R. Dellani^b, P. Stoeter^b and A. Fellgiebel^a

^a Department of Psychiatry, University of Mainz, Germany
^b Institute of Neuroradiology, University of Mainz, Germany

View larger version (93K): [in a new window]   Fig 1. Placement of regions of interest. Regions of interest (5.4 x 7.2 x 3.0 mm) for the measurement of hippocampal FA (middle) and MD (bottom) values. The T2-weighted image (top, b = 0 s/mm2) was used as an anatomic reference.

View larger version (24K): [in a new window]   Fig 2. Correlation of first and second assessments of hippocampal FA and MD values. Data points are average DTI parameter values of the selected region of interest (n = 20). FA, fractional anisotropy [x103]; MD, mean diffusivity [µm2/s].

View larger version (21K): [in a new window]   Fig 3. Cumulative frequency distributions of pooled FA and MD values and comparison with Gaussian distributions. Figures represent the distribution of average DTI parameter values (MD, left; FA, right) for all the data (ie, data of left and right hippocampus) and of first and second assessment pooled for each subject (80 data points, n = 20). D’AP-test, D’Agostino-Pearson test for deviation from normality.