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AJNR - American Journal of Neuroradiology

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Neuropathology for the Neuroradiologist: Rosettes and Pseudorosettes

F.J. Wippold, II^a,c,d and A. Perry^b

^a Neuroradiology Section, Mallinckrodt Institute of Radiology, St. Louis, Mo
^b Neuropathology Division, Department of Pathology, Washington University School of Medicine, St. Louis, Mo
^c Department of Radiology, Barnes-Jewish Hospital, St. Louis, Mo
^d Department of Radiology/Nuclear Medicine, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md

View larger version (51K): [in a new window]   Fig 1. Diagram of a typical rosette demonstrating a halo of cells surrounding a central lumen. Adapted from Ellison et al (2004)34 with permission.

View larger version (127K): [in a new window]   Fig 2. Example of a cathedral rose window. Photo courtesy of the Cathedral Basilica of St. Louis, used with permission.

View larger version (62K): [in a new window]   Fig 3. Diagram of Homer Wright rosette. A halo of cells surrounds a central hub that contains a meshwork of fibers. Adapted from Ellison et al (2004)34 with permission.

View larger version (161K): [in a new window]   Fig 4. Photomicrograph from a PNET demonstrating multiple Homer Wright rosettes. The halo-like cluster of cells in each rosette surrounds a central area of fiber-rich neuropil (H&E; original magnification 400x).

View larger version (90K): [in a new window]   Fig 5. Diagram of Flexner-Wintersteiner rosette. A halo of cells surrounds a largely empty central hub. Small cytoplasmic extensions from the cells project into the lumen. Adapted from Ellison et al (2004)34 with permission.

View larger version (148K): [in a new window]   Fig 6. Photomicrograph from a retinoblastoma showing multiple Flexner-Wintersteiner rosettes. The halo-like cluster of cells in each rosette surrounds a nearly empty appearing central lumen containing fine cytoplasmic processes (H&E; original magnification 400x). Photomicrograph generously donated by Dr. Morton Smith, Ophthalmic Pathology, Washington University, St. Louis.

View larger version (62K): [in a new window]   Fig 7. Diagram of true ependymal rosette. A halo of cells surrounds an empty lumen. Adapted from Ellison et al (2004)34 with permission.

View larger version (155K): [in a new window]   Fig 8. Photomicrograph from an ependymoma showing several true ependymal rosettes. The halo-like cluster of cells in each rosette surrounds an empty central lumen (H&E; original magnification 400x).

View larger version (66K): [in a new window]   Fig 9. Diagram of perivascular pseudorosette. A halo of cells surrounds a blood vessel. Adapted from Ellison et al (2004)34 with permission.

View larger version (155K): [in a new window]   Fig 10. Photomicrograph from an ependymoma showing 2 prominent perivascular pseudorosettes. The halo-like cluster of cells in each rosette surrounds a blood vessel. Note the several smaller true ependymal rosettes (H&E; original magnification 200x).

View larger version (40K): [in a new window]   Fig 11. Diagram of neurocytic rosette. This rosette is similar to the Homer Wright rosette, but the central fiber-rich neuropil island is larger and more irregular. Adapted from Ellison et al (2004)34 with permission.

View larger version (149K): [in a new window]   Fig 12. Photomicrograph from a central neurocytoma containing an irregularly shaped neurocytic rosette with central neuropil (H&E; original magnification 400x).