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AJNR - American Journal of Neuroradiology

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MR Imaging of the Brain in Patients Cured of Acute Lymphoblastic Leukemia—the Value of Gradient Echo Imaging

M.S.M. Chan^a, D.J. Roebuck^c, M.-P. Yuen^b, C.-K. Li^b and Y.-L. Chan^a

^a Department of Diagnostic Radiology and Organ Imaging, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China
^b Department of Pediatrics, Prince of Wales Hospital, the Chinese University of Hong Kong, Hong Kong, China
^c Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom

View larger version (81K): [in a new window]   Fig 1. Twenty-year-old woman diagnosed 14 years previously and treated with intrathecal MTX (total dose = 72 mg) and cranial radiation therapy (18 Gy). A, Transverse gradient echo image shows 2 lesions compatible with old hemorrhages (arrowheads). The structures indicated by the arrows are blood vessels. B, Transverse T2-weighted fast spin-echo image at the same level appears normal.

View larger version (165K): [in a new window]   Fig 2. Twenty-seven-year-old man diagnosed 18 years previously and treated with intrathecal MTX (total dose = 300 mg) and cranial radiation therapy (24 Gy). On coronal FLAIR image, there is grade 1 leukoencephalopathy (arrows), defined as patchy, mildly increased signal intensity in the periventricular white matter, without involvement of the subcortical U-fibers.