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Malignancy-Associated Vessel Tortuosity: A Computer-Assisted, MR Angiographic Study of Choroid Plexus Carcinoma in Genetically Engineered Mice

E. Bullitta, P.A. Wolthusenb, L. Brubakerc, W. Linc, D. Zengd and T. Van Dykeb

a Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC
b Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
c Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
d Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC


Figure 1
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  		Fig 1. Choroid dysplasia. Top row, left to right, coronal T1, T2, T1-GAD, and MRA sections. Bottom row, left, H&E–stained coronal histologic section. Bar = 200 µm. Note the thickened and somewhat disorganized choroid at left (arrows). Center and right, 3D segmented vessels with the ventricular system shown at full opacity (center) and no opacity (right). Vessels are shown from an anteroposterior (AP) view and are color-coded relative to the ventricular system with blue (outside), gold (traverse), red (inside), and cyan (exit or enter). Vessel analysis was performed upon all red vessels and upon the segments of the gold and cyan vessels lying within the region of interest. This case is tumor 19 in Table.


Figure 2
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  		Fig 2. Emerging cancer. Top row, left to right, T1, T2, T1-GAD, and MRA sections. Arrow points to multiple, tiny cancers visible in the T2 image. Bottom row, left, H&E histologic section. Note the tiny cancer foci (arrows). Bar = 200 µm. Center and right, 3D rendering of segmented vessels with the segmented ventricular system shown at full (center) and no (right) opacity from an AP view. Vessel color coding is as outlined in Fig 2. This case is tumor 15 in the Table.


Figure 3
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  		Fig 3. Typical vessel tortuosity abnormality in one of the CPC mice during early cancer development. Note the "many bends upon each larger bend" present in the highlighted (red) vessel.


Figure 4
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  		Fig 4. Terminal CPC tumor. Top row, a massive tumor is shown from left to right in T1, T2, T1-GAD, and MRA sections. Arrow points to the tumor as seen on T1-Gad. The contralateral ventricular system is dilated. Bottom row, left, H&E histologic section from this animal. Bar = 200 µm. Center and right, 3D rendering of an AP view of segmented vessels and with the segmented tumor shown at full (center) and no (right) opacity. Vessel color coding is outlined in Fig 2. This tumor is case 5 in the Table.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X