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AJNR - American Journal of Neuroradiology

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Field, Coil, and Echo-Time Influence on Sensitivity and Reproducibility of Brain Proton MR Spectroscopy

M. Inglese^a, M. Spindler^a, J.S. Babb^a, P. Sunenshine^a, M. Law^a and O. Gonen^a

^a From the Department of Radiology, New York University School of Medicine, New York, NY

View larger version (132K): [in a new window]   Fig 1. Axial, T2-weighted MR imaging of a healthy female volunteer, superimposed with the 8LR x 10AP x 1.5IS = 120 mL MR spectroscopy VOI (solid white outline), which was placed over similar anatomy (superior margin of the lateral ventricles) in all 6 subjects by a neuroradiologist. The VOI was partitioned into 8LR x 10AP voxels, 1.5 mL each. Arrows indicate the WM and GM voxels selected for the analyses in each subject.

View larger version (20K): [in a new window]   Fig 2. Real part of the GM 1H-MR spectrum acquired at 1.5T with a SEQ coil at short (30 ms), intermediate (144 ms), and long TE (288 ms) in 2 female volunteers, displayed on common intensity (vertical) and indicated chemical shift (parts per million [ppm]) scales. Note the consistent pattern of increasing NAA, Cr, and Cho SNRs with decreasing TE in both subjects and the between-subjects spectra feature consistency.

View larger version (21K): [in a new window]   Fig 3. Comparison between the real part of the GM (top) and WM (bottom) 1H-MR spectroscopy (TE = 144 ms) on common intensity and ppm scales, acquired from the same 2 voxels in a male volunteer at 1.5T with SEQ (left) and PA (right) coils. Note the higher SNRs for all metabolites in both GM and WM at with the PA versus SEQ coil.

View larger version (18K): [in a new window]   Fig 4. Real part of the GM 1H-MR spectra, at 3T with SEQ coil, from 2 healthy male volunteers, at short, intermediate, and long TEs, displayed on common intensity and chemical shift scales. Note the reduced baseline undulations at the longest TE (288 ms) in both subjects compared with the intermediate and short TEs.