Imaging-Guided Acute Ischemic Stroke Therapy: From "Time Is Brain" to "Physiology Is Brain"
R.G. Gonzáleza
a From the Neuroradiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Mass
View larger version (9K):
[in a new window]
|
Fig 1. Three outcome measures from the NINDS tPA trial.1 In a study population of 624 patients, recombinant tPA (white bar) or placebo (black bar) was administered intravenously in patients within 3 hours of stroke symptom onset and negative findings on head CT. Displayed here are percentages of patients who had good clinical outcomes at 3 months (modified Rankin Score of 0–2), symptomatic hemorrhage, and death. The long-term clinical benefit of tPA was significant (global odds ratio for a favorable outcome, 1.7; 95% confidence interval, 1.2–2.6). Compared with patients given placebo, patients treated with tPA were more likely to have minimal or no disability at 3 months on the assessment scales (50% versus 38%). Symptomatic intracerebral hemorrhage within 36 hours after the onset of stroke occurred in 6.4% of patients given tPA but in only 0.6% of patients given a placebo (P < .001). Mortality rate at 3 months was 17% in the tPA group and 21% in the placebo group (nonsignificant, P = .30).
| |
View larger version (27K):
[in a new window]
|
Fig 2. The ischemic penumbra. Occlusion of a major cerebral artery such as the proximal right MCA, illustrated here, results in changes in the hemodynamics of the brain that vary from patient to patient. With occlusion, collateral vascular channels can provide blood flow to ischemic regions. Here, collateral circulation from the right anterior cerebral artery distribution to the right MCA territory is depicted. The perfusion within the vascular territory of the occluded artery varies with some areas receiving little blood flow, whereas other areas receive near-normal amounts of blood flow. This results in 2 regions: an infarction core that represents irreversibly injured brain and an ischemic penumbra that may be clinically symptomatic but can be rescued if blood flow is restored.
| |
View larger version (16K):
[in a new window]
|
Fig 3. Blood flow and infarction. Data from awake monkeys in which an MCA was occluded.44 The open circles represent local blood flow in normal tissue, the open triangles are measurements in the periphery of the infarct, and the closed rectangles depict blood flow within the infarct. The dashed line approximates the infarction threshold; when the local CBF crosses this line, there is irreversible injury. Local CBF outside this line, but below normal levels ( 20–25 mL/100 g per minute), represents the ischemic penumbra.
| |
View larger version (24K):
[in a new window]
|
Fig 5. Outcomes in extended time window for tPA trial.81 Patients within 0–3 hours from symptom onset (group A, n = 79) were treated according to standard CT criteria. Treatment within 3–6 hours (n = 43) was decided according to protocol criteria that included a diffusion- and perfusion-weighted image–generated TTP map; criteria for tPA treatment were defined as a diffusion/perfusion mismatch >50%. Clinical outcomes for the patients in the 2 groups were not significantly different. Interestingly, more than 75% of the 56 patients considered for inclusion into the 3- to 6-hour group B had a diffusion/perfusion mismatch >50%.
| |
View larger version (71K):
[in a new window]
|
Fig 6. Using imaging-derived physiologic information to guide therapy. The patient is a 38-year-old man who was found with a severe left hemiparesis. The precise time of stroke onset was unknown. The noncontrast CT scan was remarkable for a hyperattenuated focus in the region of the right MCA (not shown). A, CT angiography demonstrates occlusion of the right MCA (arrow), but with reconstitution of distal branches likely due to collateral circulation. B, Diffusion MR imaging shows abnormal diffusion in the distribution of the right lenticulostriate arteries, but with sparing of the remainder of the MCA territory, including the cerebral cortex. C, Perfusion MR imaging displays abnormalities involving the entire right MCA territory. The time-to-minimum-perfusion map at the same level as the DWI image demonstrates a perfusion deficit that is much larger than the DWI abnormality. Because of the large diffusion/perfusion mismatch and the likely poor long-term outcome in the absence of treatment in this man with a young family, the decision was made to proceed to intra-arterial thrombolysis. D, Right common carotid angiogram demonstrates a cutoff of the right MCA, corresponding to the previously obtained CTA (arrow). E, After manipulation with a microguidewire and infusion of urokinase, right MCA flow was established (arrow). F, A follow-up head CT scan shows infarction in the region of the right corona radiata and a small portion of cerebral cortex. The patient made an excellent recovery with minor neurologic deficits at discharge.
| |
AJNR - American Journal of Neuroradiology