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AJNR - American Journal of Neuroradiology

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A Longitudinal Immunohistochemical Study of the Healing of Experimental Aneurysms After Embolization with Platinum Coils

D. Dai^a, Y.H. Ding^a, R. Kadirvel^a, M.A. Danielson^a, D.A. Lewis^a, H.J. Cloft^a and D.F Kallmes^a

^a From the Department of Radiology, Neuroradiology Research Laboratory, Mayo Clinic, Rochester, Minn

View larger version (107K): [in a new window]   Fig 1. Photomicrographs of rabbit aneurysms embolized with platinum coils show that spindle cells within the aneurysm dome at 4 weeks (A) are positive for SMA and negative for SMA at 16 weeks (B) (immunohistochemistry, antibody to SMA, original magnification x200).

View larger version (138K): [in a new window]   Fig 2. Photomicrograph of a rabbit aneurysm 10 weeks after embolization with platinum coils shows sparse cells within the dome that are positive for SMA staining (arrow); no positive cells were observed at the neck (dashed arrow). The cells at the side edge of neck (the transition zone of aneurysm wall to aneurysm neck) are positive for SMA (dotted arrow) (immunohistochemistry, antibody to SMA, original magnification x60).

View larger version (128K): [in a new window]   Fig 3. Photomicrograph of TUNEL staining for a 4-week rabbit aneurysm embolized with platinum coils. The attenuated brown or dark brown signal intensity is localized within the nuclei of the spindle cells, indicating positive staining (TUNEL, original magnification x200).