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Protective Effect of Agmatine on a Reperfusion Model After Transient Cerebral Ischemia: Temporal Evolution on Perfusion MR Imaging and Histopathologic Findings

D.J. Kima, D.I. Kima, S.K. Leea, S.H. Suha, Y.J. Leec, J. Kima, T.S. Chunga and J.E. Leeb

a Department of Radiology, Yonsei University College of Medicine, Seoul, Korea
b Department of Anatomy, Yonsei University College of Medicine, Seoul, Korea
c Department of Radiology, Pochon CHA Medical University, Sungnam, Korea


Figure 1
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  		Fig 1. Agmatine-treated cat with type I and II reperfusion.

A, Persistent hyperperfusion is noted in the left frontal lobe (type I reperfusion, arrow). Initial hyperemia in the left striatum shows hypoperfusion on the last follow-up image (type II reperfusion, arrowhead). Notice the lack of signal-intensity changes on T2-weighted (T2WI) or diffusion-weighted images (DWI.). (B) A few red-stained TUNEL-positive cells are seen in all regions of the left hemisphere. ADC indicates apparent diffusion coefficient.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X