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Widening Spectrum of a Reversible Splenial Lesion with Transiently Reduced Diffusion

J. Takanashia, A.J. Barkovichg, T. Shiiharab, H. Tadac, M. Kawatanid, H. Tsukaharad, M. Kikuchie and M. Maedaf

a Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
b Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan
c Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan
d Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
e Division of Pediatrics, Hitachi General Hospital, Hitachi, Japan
f Department of Radiology, Mie University School of Medicine, Mie, Japan
g Neuroradiology Section, Department of Radiology, University of California San Francisco, Calif


Figure 1
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  		Fig 1. Diffusion-weighted and T2-weighted images of patient 2 on day 5 showed high-signal-intensity lesions in the central portion of the splenium of the corpus callosum (SCC) and symmetric frontoparietal peripheral white matter (A–C, arrows). Follow-up study on day 12 showed no lesions on any sequences (T2-weighted image, D).


Figure 2
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  		Fig 2. Diffusion-weighted image (DWI) of patient 4 on day 2 showed an oval shaped splenial lesion (A). DWI on day 7 showed no splenial lesion, but frontal cortical lesions with reduced diffusion (B, arrows), followed by cortical T2 prolongation and atrophy on day 70 (fluid-attenuated inversion recovery, C).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X