Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?
S.J. Millsa,
T.A. Patankara,
H.A. Haroona,
D. Balériauxc,
R. Swindellb and
A. Jacksona
a Department of Imaging Science and Biomedical Engineering, Christie Hospital NHS Trust, Manchester, United Kingdom
b University of Manchester, and the Department of Medical Statistics, Christie Hospital NHS Trust, Manchester, United Kingdom
c Service de Radiologie Hôpital Erasme, Cliniques Universitaires de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium
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Fig 1. A, Cerebral blood volume (CBV) versus patient survival for tumor grades II–IV (WHO classification).
B, Ktrans versus patient survival for tumor grades II–IV (WHO classification).
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Fig 2. A, Boxplots showing median, interquartile range (box), and extreme values of cerebral blood volume (CBV) for tumor grades II–IV (WHO classification).
B, Boxplots showing median, interquartile range (box), and extreme values of Ktrans for tumor grades II–IV (WHO classification).
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Fig 3. A, Kaplan Meier survival curve for histologic grade of tumor (according to WHO classification).
B, Kaplan Meier survival curve for arbitrary groups of cerebral blood volume (CBV), irrespective of grade (group 1 [n = 6]; range, 0.60%–1.60%; group 2 [n = 7]; range, 1.88%–2.54%; group 3 [n = 7]; range, 2.80%–3.53%; group 4 [n = 7]; range, 3.56%–6.31%).
C, Kaplan Meier survival curve for arbitrary groups of Ktrans, irrespective of grade (group 1 [n = 6]; range, 0.00017–0.00054 minutes–1; group 2 [n = 7]; range, 0.001–0.008 minutes–1; group 3 [n = 7]; range, 0.009–0.025 minutes–1; group 4 [n = 7]; range, 0.027–0.056 minutes–1).
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Fig 4. Kaplan Meier survival curve for arbitrary groups of Ktrans in grade IV tumors only (group 1 [n = 5]; range, 0.0013–0.009 minutes–1; group 2 [n = 5]; range, 0.016–0.029 minutes–1; group 3 [n = 7]; range, 0.034–0.056 minutes–1).
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Fig 5. Relationship of Ktrans with patient survival in high grade (III and IV) tumors. Linear regression shows increasing survival with increasing Ktrans (ß = 0.556; R2 = 0.309; P < .01).
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