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Measuring Longitudinal White Matter Changes: Comparison of a Visual Rating Scale with a Volumetric Measurement

D.M.J. van den Heuvela, V.H. ten Damb, A.J.M. de Craenb, F. Admiraal-Behloulc, A.C.G.M. van Esa, W.M. Palma, A. Spilta, E.L.E.M. Bollend, G.J. Blauwb, L. Launere, R.G.J. Westendorpb, M.A. van Buchema on behalf of the PROSPER Study Group

a Department of Radiology, Leiden University Medical Center, the Netherlands
b Departments of Gerontology and Geriatrics, Leiden University Medical Center, the Netherlands
c Division of Image Processing, Leiden University Medical Center, the Netherlands
d Division of Neurology, Leiden University Medical Center, the Netherlands
e Division of Epidemiology, Demography Biostatistics, the National Institute on Aging, the National Institutes of Health, Bethesda, Md


Figure 1
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  		Fig 1. Computerized semiautomatic detection system for quantification of volumes of deep and periventricular WMH. Red indicates deep WMH and blue indicates periventricular WMH.


Figure 2
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  		Fig 2. 3D representation of manually segmented deep WMH (red) and periventricular WMH (blue). The lateral ventricles are presented in green. The parenchyma is displayed in yellow.


Figure 3
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  		Fig 3. Graph shows longitudinal evaluation of WMH change in 100 elderly subjects by using (A) a visual rating scale (ie, Scheltens scale) and (B) a volumetric method. Black indicates the number of subjects showing WMH regression at the end of follow-up; gray indicates the number of subjects showing no change in WMH or WMH progression at the end of follow-up.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X