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AJNR - American Journal of Neuroradiology

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Corpus Callosum Diffusion Anisotropy Correlates with Neuropsychological Outcomes in Twins Disconcordant for Traumatic Brain Injury

L. Ewing-Cobbs^a, K.M. Hasan^b, M.R. Prasad^a, L. Kramer^b and J. Bachevalier^c

^a Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Tex
^b Department of Interventional and Diagnostic Imaging, University of Texas Health Science Center at Houston, Houston, Tex
^c Department of Psychology, Emory University, Atlanta, Ga

View larger version (84K): [in a new window]   Fig 1. Comparison of conventional and DT MR imaging findings in identical (A) and fraternal (B) twins with severe TBI (right) and cotwins (left). Note the posttraumatic diminution of white matter tracts, ventriculomegaly, and significant thinning of callosal regions, particularly the genu, rostral body, and posterior body.

View larger version (40K): [in a new window]   Fig 2. Graph shows that FA values for each callosal region are reduced in the twins with TBI relative to their cotwins. Effect sizes (Cohen’s d) indicated above each region range from medium for the splenium to extremely large for the genu, rostral (ros) body, posterior (post) body, and isthmus. Ant indicates anterior.