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Diffusion Tensor Imaging in the Assessment of Normal-Appearing Brain Tissue Damage in Relapsing Neuromyelitis Optica

C.S. Yua, F.C. Linc, K.C. Lia, T.Z. Jiangc, C.Z. Zhuc, W. Qina, H. Sunb and P. Chanb

a Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences
b Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences
c National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China


Figure 1
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  		Fig 1. Examples of region of interest placement for mean diffusivity (MD) and fractional anisotropy (FA) measurements. FA images show regions of interest of medulla oblongata (A), cerebral peduncle (B), internal capsule (C), optic radiation (D), splenium and genu of corpus callosum (E), and putamen and thalamus (F).


Figure 2
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  		Fig 2. Average mean diffusivity (mm2/s) histograms of the brain tissue from patients with relapsing neuromyelitis optica (RNMO) (solid line) and control subjects (dotted line).


Figure 3
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  		Fig 3. Average fractional anisotropy histograms of the brain tissue from patients with relapsing neuromyelitis optica (RNMO) (solid line) and control subjects (dotted line).


Figure 4
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  		Fig 4. Average mean diffusivity (mm2/s) histograms of the brain white matter from patients with relapsing neuromyelitis optica (RNMO) (solid line) and control subjects (dotted line).


Figure 5
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  		Fig 5. Average mean diffusivity (mm2/s) histograms of the brain gray matter from patients with relapsing neuromyelitis optica (RNMO) (solid line) and control subjects (dotted line).


Figure 6
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  		Fig 6. Average fractional anisotropy histograms of the brain white matter from patients with relapsing neuromyelitis optica (RNMO) (solid line) and control subjects (dotted line).





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X