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Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants

A. Zachariaa, S. Ziminea, K.O. Lovblada,b, S. Warfieldc, H. Thoenyd, C. Ozdobab, E. Bossie, R. Kreisf, C. Boeschf, G. Schrothb and P.S. Hüppig

a Neuroradiology Unit, Radiology Department, Geneva University, Switzerland
b Institut für Neuroradiologie, DRNN, Inselspital CH-3010 Bern, Switzerland
c Computational Radiology Laboratory, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass
d Department of Radiology, Bern University Hospital, Bern, Switzerland
e Neonatologie, Kinderspital, Inselspital, CH-3010 Bern, Switzerland
f MR Spectroscopy and Methodology Unit, the Department of Clinical Research, University of Bern, Bern, Switzerland
g Child Development Unit, Children’s Hospital, Geneva, Switzerland


Figure 1
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  		Fig 1. Segmentation. Reconstructed coronal T2-weighted image on the left compared with the segmented image (on the right) by using the Slicer software. On the segmented image, gray matter is gray, CSF is blue, the BG are yellow, unmyelinated white matter is red, and myelinated white matter is white.


Figure 2
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  		Fig 2. Total intracranial volume. The preterm newborns at birth had a lower intracranial volume, but at term, they had a volume similar to that of the term neonates.


Figure 3
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  		Fig 3. Volume of cortical gray matter. The preterm infants at birth had a lower volume of cortical gray matter, but at term, they had a volume similar to that of the term neonates.


Figure 4
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  		Fig 4. Volume of unmyelinated white matter. The preterm neonates at birth had a lower volume of unmyelinated white matter, but at term, they had a volume similar to that of the term neonates.


Figure 5
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  		Fig 5. The relative volume of myelinated white matter showed no difference between preterms, preterms at term, and full-term infants


Figure 6
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  		Fig 6. The relative volume of BG was highest in preterms. Preterm infants at term and full-term infants had similar relative volumes of basal ganglia.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X