Advanced

AJNR - American Journal of Neuroradiology

This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ge, Y. Search for Related Content PubMed PubMed Citation Articles by Ge, Y.

Multiple Sclerosis: The Role of MR Imaging

Y. Ge^a

^a From Department of Radiology/Center for Biomedical Imaging, New York University Medical Center, New York, NY

View larger version (120K): [in a new window]   Fig 1. Axial T2-weighted images of a 43-year-old RRMS patient show prominent perivascular spaces (short arrows), which project radially and are aligned with lesions, following the course and configuration of deep venular structures. This may be associated with perivascular inflammation, which initiates the development of new lesions (long arrow). These prominent perivascular spaces might have implications for differentiating primary from secondary demyelinating lesions.

View larger version (65K): [in a new window]   Fig 2. A 30-year-old female RRMS patient shown on T2WI (A), FLAIR (B), and contrast-enhanced T1WI. The lesions on FLAIR are usually prominent and several small lesions are depicted only on FLAIR (arrows). The lesion enhancement can be nodule (as shown in this case) or ringlike on T1-weighted imaging.

View larger version (74K): [in a new window]   Fig 3. MS lesion (arrow) in corpus callosum on FLAIR imaging is failed to be picked up on T2-weighted imaging.

View larger version (14K): [in a new window]   Fig 4. Averaged magnetization transfer ratio histograms from 3 groups (healthy control, RRMS, and SPMS) for global NAGM (A) and NAWM (B) tissues. Lower normalized peak height in SPMS population indicates relatively less residual normal brain tissue compared with that in RRMS patients.

View larger version (60K): [in a new window]   Fig 5. DTI (left, b = 0), FA (middle), and MD (right) maps of a 31-year-old female patient with RRMS. The decreased value of FA and increased value of MD for the lesions (arrows) are shown in their maps. Note that the decreased FA (arrowhead) in some white matter areas is probably due to fiber crossing.

View larger version (35K): [in a new window]   Fig 6. Fiber tractography in a patient with MS (A) and a healthy volunteer (B). All the MS plaques (arrows) were marked and constructed in 3D. Note the reduced number of fibers when they traverse white matter lesions in the patient.

View larger version (31K): [in a new window]   Fig 7. Axial T2-weighed (TE/TR = 90/2500 msec) image of a 26-year-old woman MS patient superimposed with the MR spectroscopy volume of interest. Spectra from 2 lesions (2 and 4) and 2 contralateral NAWM regions (1 and 3) are shown on common intensity and chemical shift (ppm) scales.

View larger version (83K): [in a new window]   Fig 8. Axial gradient-echo imaging in a 29-year-old patient with MS (A) and a 34-year-old healthy volunteer (B). Greater hypointense signal intensities, which may be associated with excessive iron deposition, are seen in all ferruginated neurons in a patient compared with a healthy volunteer.