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AJNR - American Journal of Neuroradiology

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Diffusion Tensor Imaging in Amyotrophic Lateral Sclerosis: Volumetric Analysis of the Corticospinal Tract

S. Wang^a, H. Poptani^a, M. Bilello^a, X. Wu^a, J.H. Woo^a, L.B. Elman^b, L.F. McCluskey^b, J. Krejza^a,c and E.R. Melhem^a

^a Division of Neuroradiology, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Penn
^b Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Penn
^c Division of Neuroradiology, Department of Radiology, The Medical University of Gdansk, Gdansk, Poland

View larger version (53K): [in a new window]   Fig 1. Diffusion tensor imaging-based color map of a healthy subject. Colors indicate directions as follows: red, left-right; green, anteroposterior; blue, superior-inferior. The white line delineates manually segmented corticospinal tract (CST) (A). Reconstructed CSTs (green) are overlaid on color maps (B).

View larger version (61K): [in a new window]   Fig 2. Diffusion tensor imaging-based color maps of a healthy subject (A) and a patient with amyotrophic lateral sclerosis (ALS) (B). The left corticospinal tract (arrows) appears thinner in the patient with ALS (B).

View larger version (35K): [in a new window]   Fig 3. Region of interest (ROI) placement on the reconstruction of corticospinal tract (CST) at the level of precentral gyrus (A, white) and lower pons (B, orange). Fiber tracking images of a healthy subject (C) and a patient with amyotrophic lateral sclerosis (ALS) (D). The rectangle in C indicates section location of ROIs. Descending fibers connecting the cortex and brain stem are shown in purple. CSTs are green. The CST fibers are diminished in the patient with ALS (D).