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AJNR - American Journal of Neuroradiology

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A Dedicated Animal Model for Mechanical Thrombectomy in Acute Stroke

J. Gralla^a, G. Schroth^a, L. Remonda^a, A. Fleischmann^b, J. Fandino^c, J. Slotboom^a and C. Brekenfeld^a

^a Departments of Interventional and Diagnostic Neuroradiology, Inselspital, University of Bern, Bern, Switzerland
^b Neurosurgery, Inselspital, University of Bern, Bern, Switzerland
^c Pathology, Inselspital, University of Bern, Bern, Switzerland

View larger version (78K): [in a new window]   Fig 1. Masson trichrome–stained longitudinal section (A) showing a muscular vessel wall (V) with a thrombus (T) completely occluding the artery 90 minutes after application. A magnified view (B) of the arterial wall and the thrombus in hematoxylin-eosin-stained section revealing evenly distributed barium sulfate particles (arrows) in this whole blot thrombus. The endothelium is intact (asterisk), and no inflammatory changes are observed in the vessel wall.

View larger version (60K): [in a new window]   Fig 2. The barium sulfate–marked thrombus (arrows) during insertion into the lingual artery with (A) and without (B) digital subtraction angiography. The asterisk indicates the location of the 7F guiding catheter.

View larger version (39K): [in a new window]   Fig 3. Thrombectomy in the right ICA by using a clot retrieval device (Catch device; Balt, Montmorency, France, upper and lower marker >). The device is unfolded distally to the contrasted thrombus (A), well visualized even in the unprocessed angiogram. The thrombus is partially caught (B) and retrieved by the basket-like device (C). During the pullback maneuver, the thrombus is compressed (D) and subsequently a small fragment (asterisk) remains in the ICA, while a large part of the thrombus is removed (E). The device passes the thrombus at the tip of the 7F guiding catheter and loses this fragment. A small residual fragment is retrieved by the device (E).