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AJNR - American Journal of Neuroradiology

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Short Echo Time MR Spectroscopic Imaging for Neonatal Pediatric Imaging

D.H. Kim^a, A.J. Barkovich^a and D.B. Vigneron^a

^a From the Department of Radiology, University of California at San Francisco, San Francisco, Calif

View larger version (58K): [in a new window]   Fig 1. Volumetric dataset from a preterm neonate imaged at 31-week adjusted age. Shown are the T2 weighted images along with the spectra between the 4.0–1.0-ppm region. Regional variation is seen with the highest metabolite levels within the deep gray matter.

View larger version (33K): [in a new window]   Fig 2. Representative spectra from a voxel in Fig 1. The labeled metabolites correspond to (1) NAA, (2) Cr, (3) Cho, (4) mIns, (5) Lac, (6) Glx, and (7) macromolecular baseline in the 2.0–1.0-ppm region.

View larger version (27K): [in a new window]   Fig 3. Spectra extracted from a 33-week and a 40-week age-adjusted infant. Corresponding regions are indicated for the spectra. In general, the deep gray matter regions show higher metabolite levels indicating earlier development. Note the high levels of Cho in all spectra, which is typical of neonates. Finally, note the elevated mIns level in the calcarine gray matter of the 33-week baby.