A Systematic Literature Review of Magnetic Resonance Spectroscopy for the Characterization of Brain Tumors
W. Hollingwortha,
L.S. Medinac,
R.E. Lenkinskid,
D.K. Shibataa,
B. Bernalc,
D. Zurakowskie,
B. Comstockb and
J.G. Jarvika
a Departments of Radiology, University of Washington, Seattle, Wash
b General Internal Medicine, University of Washington, Seattle, Wash
c Department of Radiology, Miami Childrens Hospital, Miami, Fla
d Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass
e Departments of Orthopaedic Surgery and Biostatistics, Harvard Medical School, Boston, Mass

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Fig 1. Studies identified by the systematic review.
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Fig 2. Receiver operating characteristic (ROC) curves measuring the sensitivity and specificity of 1H-MR spectroscopy for distinguishing metastases from high-grade astrocytomas. The ROC curves are back-calculated from the area-under-the-curve figures provided by the authors. They approximate, but are not perfect matches, for the ROC curves based on the individual patient data.
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Fig 3. Receiver operating characteristic (ROC) curves and point estimates of sensitivity and specificity of 1H-MR spectroscopy for distinguishing high- and low-grade astrocytomas. The ROC curves are back-calculated from the area-under-the-curve figures provided by the authors. They approximate, but are not perfect matches, for the ROC curves based on the individual patient data.
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Fig 4. Sensitivity and specificity of 1H-MR spectroscopy for differentiating recurrent or residual tumor from treatment-related changes.
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