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AJNR - American Journal of Neuroradiology

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Disarrangement of Fiber Tracts and Decline of Neuronal Density Correlate in Glioma Patients—A Combined Diffusion Tensor Imaging and ¹H-MR Spectroscopy Study

E. Goebell^a, J. Fiehler^a, X.-Q. Ding^a, S. Paustenbach^a, S. Nietz^a, O. Heese^b, T. Kucinski^a, C. Hagel^c, M. Westphal^b and H. Zeumer^a

^a Department of Neuroradiology, University of Hamburg, Hamburg, Germany
^b Department of Neurosurgery, University of Hamburg, Hamburg, Germany
^c Department of Neuropathology, University of Hamburg, Hamburg, Germany

View larger version (107K): [in a new window]   Fig 1. A, Regions of interest were placed in the spectroscopic matrix on T2-weighted images (2720/126; 256 x 256 matrix; field of view, 230 x 230 mm; section thickness, 6 mm) in the tumor center (TC), the border of the tumor (TB), the normal-appearing white matter adjacent to the tumor (TNWM), and in the white matter of the contralateral hemisphere (NWMC). B, After reslicing and coregristration with the T2-weighted images, the ROIs were transferred to the FA maps (4900/90 ms; 256 x 256 matrix; field of view, 230 x 230 mm; section thickness, 3 mm; b values, 0, 1500 seconds/mm2; EPI factor, 36).

View larger version (12K): [in a new window]   Fig 2. Median FA values and NAA ratios in the different volumes of interest in the patients.

View larger version (14K): [in a new window]   Fig 3. Box plot of the N-acetylaspartate/creatine ratios in patients and the control group.

View larger version (14K): [in a new window]   Fig 4. Box plot of the N-acetylaspartate/choline ratios in patients and the control group.

View larger version (14K): [in a new window]   Fig 5. Box plot of the FA values in patients and the control group.

View larger version (13K): [in a new window]   Fig 6. Correlation of median FA values and NAA ratios in the different volumes of interest.

View larger version (24K): [in a new window]   Fig 7. Distribution of individual FA values of the patients in relation to the corresponding NAA ratios.